Allosteric regulation of G-protein-linked receptors.
نویسندگان
چکیده
29 Roche, P. C., Ryan, R. J. and McCormick, D. J. (1992) Endocrinology (Baltimore) 131,268-274 Atassi, M. Z., Manshouri, T. and Sakata, S. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 3613-3617 Dattatreyamurty, B. and Reichert, L. E., Jr. (1992) Mol. Cell. Endocrinol. 87, 917 Acher, R. (1993) Regul. Pept. 45, 1-13 Yamano, Y., Ohyama, K., Chaki, S., Guo, D.-F. and Inagami, T. (1992) Riochem. Biophys. Res. Commun. 187, 1426-1431 Iwashina, M., Mizuno, T., Hirose, S., Ito, T. and Hagiwara, H. (1994) J. Biochem. (Tokyo) 115,563-567 Manning, M., Bankowski, K. and Sawyer, W. H. (1987) in Vasopressin (Gash, D. M. and Boer, G. J., eds.), pp. 335-368, Plenum Press, New York and London Queheneberger, 0.. Prossnitz, E. R., Cavanagh, S. I,., Cochrane, C. G. and Ye, R. D. (1993) J. Biol. Chem. 268,18167-18175 Perez, H. D., Holmes, R., Vilander, L. R., Adams, R. R., Manzana, W., Jolley, D. and Andrews, W. H. (1993) J. Biol. Chem. 268,2292-2295 Fong, T. M., Huang, R.-R. C. and Strader. C. L). (1992) J. Biol. Chem. 267,25664-25667 Beinborn, M., Lee, Y.-M., McBride, E. W., Quinn, S. M. and Kopin, A. S. (1993) Nature (London) 362, 348-350 30
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ورودعنوان ژورنال:
- Biochemical Society transactions
دوره 23 1 شماره
صفحات -
تاریخ انتشار 1995